Table of Contents
Contributors ix
Foreword xvii
Preface xix
I. Clinical Aspects of Urinary Tract Infections
1 Anatomy and Physiology of the Urinary Tract: Relation to Host Defense and Microbial Infection 3Duane R. Hickling, Tung-Tien Sun, and Xue-Ru Wu
2 Clinical Presentations and Epidemiology of Urinary Tract Infections 27Suzanne E. Geerlings
3 Diagnosis, Treatment, and Prevention of Urinary Tract Infection 41Paula Pietrucha-Dilanchian and Thomas M. Hooton
4 Urinary Tract Infections in Infants and Children 69Theresa A. Schlager
5 The Vaginal Microbiota and Urinary Tract Infection 79Ann E. Stapleton
6 Asymptomatic Bacteriuria and Bacterial Interference 87Lindsay E. Nicolle
7 Bacterial Prostatitis: Bacterial Virulence, Clinical Outcomes, and New Directions 121John N. Krieger and Praveen Thumbikat
8 Urosepsis: Overview of the Diagnostic and Treatment Challenges 135Florian M. E. Wagenlehner, Adrian Pilatz, Wolfgang Weidner, and Kurt G. Naber
II. Origins and Virulence Mechanisms of Uropathogenic Bacteria
9 Reservoirs of Extraintestinal Pathogenic Escherichia coli 161Amee R. Manges and James R. Johnson
10 Origin and Dissemination of Antimicrobial Resistance among Uropathogenic Escherichia coli 179Lisa K. Nolan, Ganwu Li, and Catherine M. Logue
11 Population Phylogenomics of Extraintestinal Pathogenic Escherichia coli 207Jérôme Tourret and Erick Denamur
12 Virulence and Fitness Determinants of Uropathogenic Escherichia coli 235Sargurunathan Subashchandrabose and Harry L. T. Mobley
13 Uropathogenic Escherichia coli-Associated Exotoxins 263Rodney A. Welch
14 Structure, Function, and Assembly of Adhesive Organelles by Uropathogenic Bacteria 277
Peter Chahales and David G. Thanassi
15 Pathoadaptive Mutations in Uropathogenic Escherichia coli 331Evgeni Sokurenko
16 Invasion of Host Cells and Tissues by Uropathogenic Bacteria 359Adam J. Lewis, Amanda C. Richards, and Matthew A. Mulvey
17 Proteus mirabilis and Urinary Tract Infections 383Jessica N. Schaffer and Melanie M. Pearson
18 Epidemiology and Virulence of Klebsiella pneumoniae 435Steven Clegg and Caitlin N. Murphy
19 Gram-Positive Uropathogens, Polymicrobial Urinary Tract Infection, and the Emerging Microbiota of the Urinary Tract 459Kimberly A. Kline and Amanda L. Lewis
20 Integrated Pathophysiology of Pyelonephritis 503Ferdinand X. Choong, Haris Antypas, and Agneta Richter-Dahlfors
III. Host Responses to Urinary Tract Infections and Emerging Therapeutics
21 Susceptibility to Urinary Tract Infection: Benefits and Hazards of the Antibacterial Host Response 525Ines Ambite, Karoly Nagy, Gabriela Godaly, Manoj Puthia, Björn Wullt, and Catharina Svanborg
22 Innate Immune Responses to Bladder Infection 555Byron W. Hayes and Soman N. Abraham
23 Host Responses to Urinary Tract Infections and Emerging Therapeutics: Sensation and Pain within the Urinary Tract 565Lori A. Birder and David J. Klumpp
24 Drug and Vaccine Development for the Treatment and Prevention of Urinary Tract Infections 589Valerie P. O’Brien, Thomas J. Hannan, Hailyn V. Nielsen, and Scott J. Hultgren
Index 647