Vascular Disease and Injury: Preclinical Research / Edition 1

by Daniel I. Simon, Campbell Rogers

Overview

A panel of expert clinical researchers offer a practical guide to the key animal models used in vascular disease. These experts examine critical issues related to vascular disease and injury in five major areas: acute mechanical injury and vascular repair, arterial thrombosis, chronic atherosclerosis, vascular disease in transplanted vessels, and vascular disease in systemic and pulmonary arterial hypertension. Up-to-date and highly practical, Vascular Disease and Injury: Preclinical Studies provides a comprehensive review that not only illuminates the current status of cardiovascular research, but also offers vascular biologists and cardiologists a detailed how-to guide to the development of the many powerful new therapeutics now emerging.

Product Details

ISBN-13:	9780896037533
Publisher:	Springer-Verlag New York, LLC
Publication date:	11/09/2000
Series:	Contemporary Cardiology
Edition description:	2001
Pages:	348
Product dimensions:	5.98(w) x 9.02(h) x 0.04(d)

About the Author

Simon, Daniel I., MD (Brigham and Women's Hospital); Rogers, Campbell, MD (Brigham and Women's Hospital)

Table of Contents

I Acute Mechanical Injury and Vascular Repair.- 1 Mechanical Injury in Normal and Atherosclerotic Rabbit Iliac Arteries.- 2 The Porcine Model of Coronary Restenosis.- 3 Atherosclerotic Porcine Coronary Stent Model: Technical Methods for Preclinical Studies.- 4 Nonhuman Primate Models of Arterial Injury and Repair.- 5 Experimental Models of Arteriovenous Grafting.- 6 Wire Denudation and Ligation Models of the Mouse Carotid Artery.- 7 Endothelial Denudation and Arterial Dilation in the Mouse.- 8 Vascular Phohemical Injury in the Mouse.- 9 Mouse Model of Transluminal Femoral Artery Injury.- II Models of Arterial Thrombosis.- 10 A Murine Model of Arterial Injury and Thrombosis.- 11 Folts Cyclic Flow Animal Model for Studying In Vivo Platelet Activity and Platelet Interactions with Damaged Arterial Walls.- III Chronic Atherosclerotic Models.- 12 Mouse Models of Atherosclerosis.- 13 Rabbit Models of Atherosclerosis.- 14 Atherosclerosis in Nonhuman Primates.- IV Vascular Disease in Transplanted Vessels.- 15 Murine Carotid Loop Model of Transplant Vascular Disease.- 16 Murine Heterotopic Model of Transplant Arteriopathy.- 17 Hyperacute Vascular Rejection: Lessons from Pig-to-Primate Xenotransplantation.- V Vascular Disease in Models of Arterial Hypertension.- 18 Methods for Examining Cerebrovascular Disease in Experimental Models of Hypertension.- 19 Monocrotaline-Induced Pulmonary Hypertension in Rats.- 20 Chronic Pulmonary Hypertension in the Hypoxic Rat and in the Sheep Following Continuous Air Embolization.- VI Animal Care and Tissue Processing.- 21 Veterinary Issues and Anesthesia Options.- 22 Histological and Immunohishemical Methods for Vascular Animal Model Studies.

Editorial Reviews

A practical guide to the key animal models used in vascular disease research. The 22 chapters examine issues related to vascular disease and injury in five major areas: acute mechanical injury and vascular repair, arterial thrombosis, chronic atherosclerosis, vascular disease in transplanted vessels, and vascular disease in systemic and pulmonary arterial hypertension. Models using transgenic mice are a particular focus of each section. Each chapter provides equipment lists; sources of animals, diet, and reagents; and schematic diagrams. Key points regarding survival strategy, choice of anesthesia and analgesia, and veterinary issues are also reviewed, as are the basic histopathologic methods for tissue harvesting, fixation, and electron microscopy preparation. Topics include the porcine model of coronary restenosis, experimental models of arteriovenous grafting, a murine cartoid loop model of transplant vascular disease, and hyperacute vascular rejection in pig to primate xenotransplantation. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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