Vascular Smooth Muscle: Structure And Function In Health And Disease

by Chi-ming Hai

Overview

This book presents key concepts in the structure and function of vascular smooth muscle cells in health and disease. Supplemental reading may be drawn from the extensive references listed at the end of each chapter. Vascular smooth muscle cell is the major cell type in blood vessels. Dysfunction of vascular smooth muscle cells is an important cause of vascular diseases, for example, atherosclerosis, hypertension, and circulatory shock. Vascular smooth muscle cells are phenotypically plastic, capable of switching between two major phenotypes — contractile/differentiated phenotype and invasive/proliferative phenotype in response to environmental clues. Chapter 1 introduces the major areas of research presented in this monograph. Chapters 2 to 4 address the structure and function of the contractile/differentiated phenotype of vascular smooth muscle cell. Chapters 5 and 6 address the developmental basis of vascular smooth muscle cell phenotype and structure and function of podosomes (invasive organelles) in the invasive/proliferative phenotype of vascular smooth muscle cell. Chapters 7 to 9 address the role of vascular smooth muscle cell dysfunction in vascular diseases — atherosclerosis, hypertension, and circulatory shock.

Product Details

ISBN-13:	9789813144057
Publisher:	World Scientific Publishing Company, Incorporated
Publication date:	12/01/2016
Pages:	308
Product dimensions:	6.10(w) x 9.10(h) x 0.80(d)

Table of Contents

1 Introduction Chi-Ming Hai 1

2 Structure of Differentiated/Contractile Vascular Smooth Muscle Cells Thomas J. Eddinger 7

3 Vascular Structure and Function Paul H. Ratz 47

4 Actin Filament Dynamics During Vascular Smooth Muscle Contraction William C. Cole Michael P. Walsh 145

5 Developmental Basis of Vascular Smooth Muscle Cell Phenotypes Christine Cheung B. C. Narmada 165

6 Regulation of Podosomes in Vascular Smooth Muscle Cell Invasion of the Extracellular Matrix Alan Mak 183

7 Vascular Smooth Muscle Cell Proliferation and Invasion in Atherosclerosis Chi-Ming Hai 213

8 The Role of Non-coding RNA in the Control of Vascular Contractility and Disease C. J. Nicholson K. G. Morgan 239

9 Vascular Smooth Muscle Cells as Therapeutic Target for the Treatment of Circulatory Shock Liangming Liu Teo Li Chengyang Duan 263