Table of Contents
Preface ix
Preface to the First Edition xi
Acknowledgments xiii
Chapter 1 Designer Mice 1Scope and sourcebooks
Chapter 2 Of Unicorns and Chimeras 10How to generate a line of transgenic or knockout mouse for behavioural phenotyping
Chapter 3 General Health 42Give your mouse a physical
Chapter 4 Motor Functions 62Open field, holeboard, rotarod, balance, grip, circadian activity, circling, stereotypy, ataxic gait, seizures
Chapter 5 Sensory Abilities 86Olfaction, vision, hearing, taste, touch, nociception
Chapter 6 Learning and Memory 110Morris swim task, spatial mazes, cued and contextual conditioning, conditioned taste aversion, conditioned eyeblink, olfactory discrimination, social recognition, passive avoidance, schedule controlled operant tasks, motor learning, attention
Chapter 7 Feeding and Drinking 164Daily consumption, restricted access, choice tests, microstructural analysis
Chapter 8 Reproductive Behaviors 186Sexual and parental behaviors
Chapter 9 Social Behaviors 206Social interaction, nesting, grooming, juvenile play, aggression
Chapter 10 Emotional Behaviors: Animal Models of Psychiatric Diseases 226Mouse models of fear, anxiety, depression, schizophrenia
Chapter 11 Reward 266Self-administration of addictive drugs, conditioned place preference
Chapter 12 Neurodevelopment and Neurodegeneration 290Assaying behaviors in infant, juvenile, and aged mice
Chapter 13 Putting It All Together 322Choice of tests, order of testing, number of mice, equipment, housing and testing environment
Chapter 14 The Next Generation 344Conditional and inducible mutations, viral vector gene delivery, RNA silencing, quantitative trait loci analysis, DNA microarrays, chemical mutagenesis, gene therapy, ethical issues
References 383
Index 503