5
1
9780306478383
Wnt Signaling in Development / Edition 1 available in Hardcover
- ISBN-10:
- 0306478382
- ISBN-13:
- 9780306478383
- Pub. Date:
- 10/31/2003
- Publisher:
- Springer US
- ISBN-10:
- 0306478382
- ISBN-13:
- 9780306478383
- Pub. Date:
- 10/31/2003
- Publisher:
- Springer US
Hardcover
$169.99
Current price is , Original price is $169.99. You
Buy New
$169.99
$169.99
169.99
In Stock
Overview
Wnt genes code for a family of secreted glycoproteins which fulfil important functions during the development of vertebrates and invertebrates. Wnts regulate as different aspects as differentiation, proliferation, cell migration, and cell polarity. Wnt proteins are able to activate different intracellular signaling cascades.
This book describes different aspects of Wnt signaling during development of different species like the mouse, Xenopus, chicken, C. elegans or Drosophila and in different cellular contexts like heart formation or limb bud patterning. By doing such, this book provides, for the first time in printed form, an overview of the function of Wnt proteins during development.
This book will be of interest to all professionals in the field of Wnt signaling, signal transduction or animal development.
Product Details
ISBN-13: | 9780306478383 |
---|---|
Publisher: | Springer US |
Publication date: | 10/31/2003 |
Series: | Molecular Biology Intelligence Unit |
Edition description: | 2003 |
Pages: | 280 |
Product dimensions: | 6.10(w) x 9.25(h) x 0.04(d) |
Table of Contents
Preface | xii | |
1. | Wnt Signal Transduction Pathways: An Overview | 1 |
Abstract | 1 | |
Introduction | 1 | |
Wnt/[beta]-Catenin Signaling | 4 | |
The Wnt/Ca[superscript 2+] Pathway in Vertebrates | 8 | |
Planar Cell Polarity Signaling, or the Wnt/JNK Pathway | 8 | |
Outlook | 9 | |
2. | Secreted Antagonists/Modulators of Wnt Signaling | 15 |
Abstract | 15 | |
Introduction | 15 | |
Secreted Frizzled-Related Protein (sFRPs) | 16 | |
Domain Structure of sFRP | 16 | |
Mechanism of Wnt Signaling Modulation | 19 | |
Expression and Function of sFRP | 20 | |
Wnt-Inhibitory Factor-1 (WIF-1) | 20 | |
Cerberus | 21 | |
Dickkopf | 23 | |
Wingful/Notum in Drosophila | 28 | |
Conclusion | 30 | |
3. | Wnt/Wingless Signaling in Drosophila | 35 |
Abstract | 35 | |
Introduction | 35 | |
The Wg Pathway | 36 | |
Specificity in Wg Signaling | 40 | |
Does Wg Always Act as a Morphogen? | 42 | |
D WNT-4 Controls Cell Movement through a Unique Signaling Pathway | 42 | |
4. | Wnt Signaling and the Establishment of the Dorsal-Ventral Axis in Xenopus | 47 |
Abstract | 47 | |
Introduction | 47 | |
Cortical Rotation and Establishment of Asymmetry Along the Dorsal-Ventral Axis | 48 | |
Roles of Wnt and Frizzled in the Specification of Dorsal Cell Fates | 51 | |
Transport and Asymmetric Accumulation of Dishevelled | 54 | |
Stabilization of [beta]-Catenin on the Dorsal Side of the Embryo | 56 | |
[beta]-Catenin, XTCF-3, and Activation of Dorsal-Specific Gene Expression | 58 | |
The Destruction Complex and Ventral Inhibition of Wnt Signaling | 59 | |
Ventral Repression of Dorsal-Specific Genes | 62 | |
Ventral Inhibition of WNT/[beta]-Catenin Signaling by the Wnt/Ca[superscript 2+] Pathway | 62 | |
Other Potential Regulators of WNT Signaling during Axis Formation | 63 | |
A Working Model for the Function of Wnt Signaling in the Patterning of the Dorsal-Ventral Axis in Xenopus | 63 | |
Major Unresolved Issues | 65 | |
5. | The Role of WNT Signaling in Vertebrate Head Induction and the Organizer-Gradient Model Dualism | 71 |
Abstract | 71 | |
Introduction | 71 | |
The Vertebrate Organizer | 72 | |
Classical Models for Anteroposterior Axis Formation | 72 | |
Wnt/[beta]-Catenin Signaling Antagonizes the Vertebrate Head Organizer | 74 | |
Tissues with Posteriorizing Activity Express WNTs | 75 | |
The Two Inhibitor Model for Head Induction | 75 | |
Anterior Organizing Centers Express WNT Inhibitors | 79 | |
A Transforming Gradient of Wnt/[beta]-Catenin Activity Regulates AP Neural Patterning | 80 | |
Wnt Signaling and Gastrulation Movements | 81 | |
Later Roles of WNTs | 81 | |
Conclusions and Outlook | 82 | |
6. | Epithelial Planar Cell Polarity in Drosophila | 90 |
Abstract | 90 | |
Epithelial Planar Cell Polarity | 90 | |
Planar Cell Polarity in Drosophila | 91 | |
Wnt/Frizzled Signaling and Planar Cell Polarity Establishment | 92 | |
Frizzled Signaling and Its Link to the Other PCP Genes | 95 | |
Tissue Specific Responses to PCP Signaling | 97 | |
General and Evolutionary Implications | 99 | |
7. | Patterning the Vertebrate Neural Plate by Wnt Signaling | 102 |
Summary | 102 | |
Introduction | 102 | |
Induction of the Neural Plate | 104 | |
Anteroposterior Patterning of the Neural Plate | 106 | |
Dorsoventral Patterning of the Neuroepithelium | 107 | |
Neural Crest Induction and Diversification | 109 | |
Neural Crest Apoptosis | 111 | |
Conclusions | 112 | |
8. | Wnts in Kidney and Genital Development | 117 |
Abstract | 117 | |
Introduction | 117 | |
Kidney Development in the Mouse | 118 | |
Role of Wnt Genes in Metanephric Kidney Development | 122 | |
Wnt Signaling during Kidney Development--Perspectives from Studies in Alternative Vertebrate Models | 126 | |
Pro- and Mesonephric Kidneys as Simplified Models of Nephrogenesis | 127 | |
Wnt Signaling in the Pro- and Mesonephric Kidneys | 129 | |
Wnts in Kidney Organogenesis: Conclusions from a Multi-Species Approach | 131 | |
Genital Development in the Mouse | 133 | |
Role of Wnt Genes in Genital Development | 136 | |
Sexy Wnts: Losing Them Makes a Difference | 139 | |
A Wnty but Promising Future | 140 | |
9. | Wnts in Muscle Development | 146 |
Abstract | 146 | |
Introduction | 146 | |
Epithelialization of Paraxial Mesoderm and Somite Formation | 147 | |
Formation, Maintenance, and Patterning of the Dermomyotome | 147 | |
Epaxial Myogenesis | 149 | |
Hypaxial Myogenesis | 151 | |
Concluding Remarks | 152 | |
10. | Wnt Signaling in Limb Development | 156 |
Introduction | 156 | |
A Role for Wnt Signaling in Limb Bud Initiation | 157 | |
Wnt Signaling and Limb Bud Outgrowth | 159 | |
Limb Bud Patterning--A Role for Wnt Signaling in Establishing the Dorso-Ventral Axis and Beyond | 160 | |
Roles of Wnt Signaling in Appendicular Skeletogenesis | 162 | |
11. | Wnt/Wg and Heart Development | 170 |
Abstract | 170 | |
Introduction to Drosophila Cardiogenesis | 170 | |
Wg Signaling in Drosophila Cardiogenesis | 172 | |
Introduction to Vertebrate Cardiogenesis | 173 | |
Wnt Signaling in Vertebrate Cardiogenesis | 175 | |
Vertebrate Cardiogenesis Involves Different Wnt Signal Transduction Cascades | 176 | |
Conclusion and Future Perspectives | 179 | |
12. | Wnt Signaling in C. elegans | 184 |
Abstract | 184 | |
Introduction | 184 | |
Catalog of C. elegans Wnt Pathway Components | 184 | |
The Three C. elegans [beta]-Catenins Are Involved in Distinct Processes | 187 | |
A Canonical Wnt Pathway Controls the Migration of the Descendants of the QL Neuroblast | 188 | |
Embryonic Endoderm Introduction | 190 | |
Unusual Aspects of Wnt Signaling during Endoderm Induction | 191 | |
Wnt Signaling Might Directly Target the Cytoskeleton to Control Mitotic Spindle Orientation | 192 | |
Wnt and Ras Pathways Control P12 Cell Fate | 193 | |
Wnt Signaling in Vulval Development | 194 | |
An Unusual Wnt Pathway Controls T Cell Polarity | 197 | |
Gonad Polarity | 200 | |
Wnt Pathways Might Interact to Control V5 Cell Polarity | 202 | |
Sensory Ray Formation | 203 | |
Themes and Remaining Questions in Worm Wnt Signaling | 205 | |
13. | The Wnt Gene Family and the Evolutionary Conservation of Wnt Expression | 210 |
Abstract | 210 | |
Introduction | 210 | |
Recent Phylogenetic Analyses Fail to Resolve the Evolutionary History of the Wnt Gene Family | 211 | |
The Role of Wnt Genes in Establishing the Early Anteroposterior Axis in Deuterostomes | 212 | |
Echinoderms and Hemichordates | 213 | |
Ascidians | 215 | |
Amphioxus | 216 | |
Vertebrates | 218 | |
Evolutionary Conservation of Wnt Gene Involvement in Axial Patterning of Protostomes, Deuterostomes, and Cnidarians | 221 | |
Wnt Genes and Body Elongation from the Chordate Tail Bud | 222 | |
Conservation of Wnt Signaling in the Paraxial Mesoderm in Amphioxus and Vertebrates | 223 | |
The Roles of Wnt Genes in Patterning the Chordate Notochord | 225 | |
Is There an Evolutionary Conservation of Wnt Signaling in Segmentation between Chordates and Protostomes? | 225 | |
Evolutionary Conservation of the Roles of Wnt Genes in Convergent Extension and Planar Polarity Signaling | 226 | |
The Involvement of Wnt Genes in Patterning the Developing Central Nervous System | 227 | |
Conclusions | 228 | |
14. | Wnt Signaling and Cell Migration | 240 |
Abstract | 240 | |
Introduction | 240 | |
Wnt/Ca[superscript 2+]-Signaling Blocks Convergent Extension Movement | 243 | |
Wnt Signals Influence the Migrational Behavior of Myocytes | 247 | |
Perspectives | 248 | |
15. | GSK3-Signal Regulation of Pattern Formation in Dictyostelium: Wnt-Like Pathways during Non-Canonical Multicellular Development | 251 |
Abstract | 251 | |
Introduction | 251 | |
Antagonistic Regulation of Cell Fate Determination in Dictyostelium by the 7-Transmembrane cAMP Receptors CAR3 and CAR4 | 252 | |
GSK3, a Developmental Switch Regulating Anterior/Posterior Axis Formation | 253 | |
ZAK1 and PTPase Regulate Tyrosine Phosphorylation and Activity of GSK3 | 254 | |
Downstream Targets of GSK3 Aar ([beta]-Catenin) | 256 | |
Perspectives--Integrating Tyrosine Phosphorylation with Other Signaling Components | 258 | |
Index | 263 |
From the B&N Reads Blog
Page 1 of