Wound Healing, Fibrosis, and the Myofibroblast: A Historical and Biological Perspective

by Giulio Gabbiani, Matteo Coen, Fabio Zampieri

Overview

Wound Healing, and the Myofibroblast: A Historical and Biological Perspective is the fruit of an interdisciplinary and international collaboration involving a historian of medicine (Dr. Zampieri), a physician (Dr. Coen), and a researcher (Prof. Gabbiani, world-renowned for his discovery of the myofibroblast). This book aims to draw a concise yet complete description of the conceptual evolution of wound healing, fibrosis and fibrosis-related pathologies from antiquity to present time, as well as commenting on the role of the myofibroblast and the key cell type essential for tissue repair and fibrosis (from its identification in 1971 throughout its 50-years-old history).

By viewing this complex and century-long history from different perspectives, the book's authors aim to draw an exhaustive overview, with the hope of inspiring new and fruitful basic and clinical research.

Product Details

ISBN-13:	9780323905466
Publisher:	Elsevier Science
Publication date:	09/30/2021
Pages:	132
Product dimensions:	6.00(w) x 9.00(h) x 0.00(d)

About the Author

Giulio Gabbiani has obtained an MD degree at the University of Pavia (Italy) and a PhD degree at the University of Montreal (Canada). He has been Research Associate at the Department of Pathology of Harvard Medical School, Professor at the Department of Pathology and Immunology of the University of Geneva (Switzerland), where he is now Emeritus Professor. He has been Secretary and President of the European Cytoskeleton Forum, Secretary and Chairman of the European Vascular Biology Association, Secretary of the European Tissue Repair Society. He has received several distinctions including a degree of Doctor Honoris Causa from the University of Gothenburg (Sweden) and from the University of Limoges (France). Giulio Gabbiani’s interests span from the biology of the myofibroblast (which he discovered in 1971), to mechanisms of fibrosis development and to the biology of arterial smooth muscle cell including its involvement in atherosclerosis.

Matteo Coen MD, MD-PhD has obtained a doctorate in medicine (MD), followed by a specialization in vascular surgery at the University of Ferrara (Italy) and a doctorate in medical sciences (“MD-PhD”) at the Faculty of Medicine of Geneva. He has then joined the Service of General Internal Medicine of the University Hospitals of Geneva, where he is actually chief resident, and has attained a specialization in internal medicine. Matteo Coen has also a keen interest in medical education. Alongside his clinical work and research activities in internal medicine, he is a member of the Unit of Development and Research in Medical Education (UDREM) of the University of Geneva, where he participates in various teaching and research projects.

Fabio Zampieri has a PhD in Philosophy of Science from the University of Padova (Italy), and PhD in History of Medicine from the University of Geneva (Switzerland). He is is actually professor of History of Medicine at the University of Padova. He teaches human sciences, history of medicine, and bioethics to medicine students. His fields of research ranges from the history of prehistoric medicine to contemporary biomedical sciences. He is particularly interested in the history of cardiology and pathology, as well as in the impact of Darwian concepts on medical sciences. He is a renowned expert on the figure of Giovanni Battista Morgagni and of Evolutionary Medicine.

Table of Contents

1. Introduction
2. Fibrous Tissue, Fibrosis and the Fibroblast
3. Wound healing and Wound Contraction
4. Fibrotic Diseases
5. The Myofibroblast: Role in Fibrosis Development
6. Conclusions and Perspectives
7. Bibliography

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From the Publisher

Explores how the concept of fibrosis was generated, how it evolved during the story of medicine, and its links to modern research and medicine