Clinical Virology / Edition 4

by Douglas D. Richman, Richard J. Whitley, Frederick G. Hayden

Overview

The essential reference of clinical virology

Virology is one of the most dynamic and rapidly changing fields of clinical medicine. For example, sequencing techniques from human specimens have identified numerous new members of several virus families, including new polyomaviruses, orthomyxoviruses, and bunyaviruses.

Clinical Virology, Fourth Edition, has been extensively revised and updated to incorporate the latest developments and relevant research. Chapters written by internationally recognized experts cover novel viruses, pathogenesis, epidemiology, diagnosis, treatment, and prevention, organized into two major sections:

• Section 1 provides information regarding broad topics in virology, including immune responses, vaccinology, laboratory diagnosis, principles of antiviral therapy, and detailed considerations of important organ system manifestations and syndromes caused by viral infections.
• Section 2 provides overviews of specific etiologic agents and discusses their biology, epidemiology, pathogenesis of disease causation, clinical manifestations, laboratory diagnosis, and management.

Clinical Virology provides the critical information scientists and health care professionals require about all aspects of this rapidly evolving field.

Product Details

ISBN-13:	9781555819422
Publisher:	Wiley
Publication date:	12/20/2016
Series:	ASM Books
Edition description:	4th ed.
Pages:	1489
Sales rank:	1,053,596
Product dimensions:	8.40(w) x 11.10(h) x 2.40(d)

About the Author

Richman, Douglas D., MD (UCSD); Whitley, Richard J., MD (Univ of Alabama); Hayden, Frederick G., MD (Univ of Virginia)

The contributors represent the specialties of virology, immunology, microbiology, infectious disease, internal medicine, and pathology. Most are from hospitals, universities, and research centers in nine countries, including the U.S., the U.K., Australia, and Italy. Institutions prominently represented include National Institute of Allergy and Infectious Diseases, CDC, Baylor, Columbia, Univ of Virginia, and Univ of Alabama-Birmingham.

Table of Contents

Table of Contents


Contents



1. Introduction

Douglas D. Richman, Richard J. Whitley, and Frederick G. Hayden



Section I. Viral Syndromes and General Principles



2. Respiratory Infections

John J. Treanor

3. Viral Central Nervous System Infections

Kevin A. Cassady and Richard J. Whitley

4. Gastrointestinal Syndromes

Manish Patel and Roger I. Glass

5. Viral Hepatitis

Andrew W. Tai and Jules L. Dienstag

6. Infections in Organ Transplant Recipients

John A. Zaia

7. Viral Myocarditis

Jeffrey A. Towbin

8. Viral Infections of the Skin

Brenda L. Bartlett and Stephen K. Tyring

9. Viral Hemorrhagic Fevers: a Comparative Appraisal

Mike Bray and Karl M. Johnson

10. Viral Disease of the Eye

Garry Shuttleworth and David Easty

11. Antiretroviral Agents

Magdalena E. Sobieszczyk, Barbara S. Taylor, and Scott M. Hammer

12. Antiherpesvirus, Anti-Hepatitis Virus, and Anti-Respiratory Virus Agents

Michael T. Yin, James C. M. Brust, Hong Van Tieu, and Scott M. Hammer

13. Diagnosis of Viral Infections

Guy Boivin, Tony Mazzulli, Martin Petric, and Michel Couillard

14. Immune Responses to Viruses

Jonathan W. Yewdell, Theodore C. Pierson, and Jack R. Bennink

15. Immunization against Viral Diseases

Julie E. Martin and Barney S. Graham

16. Gene Therapy and Viruses

Donald B. Kohn, Barrie J. Carter, Paolo Grandi, and Joseph C. Glorioso

17. Chronic Fatigue and Postinfective Fatigue Syndromes

Andrew R. Lloyd, Ian Hickie, and Denis Wakefield



Section II. The Agents



Part A: DNA Viruses



18. Poxviruses

R. Mark Buller and Frank Fenner

19. Herpes Simplex Viruses

Richard J. Whitley and Bernard Roizman

20. Cercopithecine Herpesvirus 1 (B Virus)

Richard J. Whitley

21. Varicella-Zoster Virus

Anne A. Gershon and Saul J. Silverstein

22. Cytomegalovirus

Paul David Griffiths, Vincent Clive Emery, and Richard Milne

23. Human Herpesvirus 6 and Human Herpesvirus 7

Koichi Yamanishi and Yasuko Mori

24. Epstein-Barr Virus

Katherine Luzuriaga and John L. Sullivan

25. Kaposi’s Sarcoma-Associated Herpesvirus

Patrick S. Moore and Yuan Chang

26. Adenoviruses

Olli Ruuskanen, Jordan P. Metcalf, Olli Meurman, and Göran Akusjärvi

27. Polyomaviruses

John E. Greenlee and Frank J. O’Neill

28. Papillomavirus

William Bonnez

29. Human Parvoviruses

Larry J. Anderson and Dean D. Erdman

30. TT Virus

Peter Simmonds

31. Hepatitis B Virus

Alexander J. V. Thompson, Sally J. Bell, and Stephen A. Locarnini



Part B: RNA Viruses



32. Human Lymphotropic Viruses: HTLV-1 and HTLV-2

William A. Blattner and Manhattan E. Charurat

33. Human Immunodeficiency Virus

John C. Guatelli, Robert F. Siliciano, Daniel R. Kuritzkes, and Douglas D. Richman

34. Colorado Tick Fever Virus and Other Arthropod-Borne Reoviridae

Steven Yukl and Joseph K. Wong

35. Rotaviruses

Manuel A. Franco and Harry B. Greenberg

36. Respiratory Syncytial Virus, Human Metapneumovirus, and Parainfluenza Viruses

John V. Williams, Pedro A. Piedra, and Janet A. Englund

37. Measles Virus

William J. Moss and Diane E. Griffin

38. Mumps Virus

John W. Gnann, Jr.

39. Zoonotic Paramyxoviruses

Paul A. Rota, Thomas G. Ksiazek, and William J. Bellini

40. Rhabdoviruses

Thomas P. Bleck and Charles E. Rupprecht

41. Filoviruses

Mike Bray

42. Influenza Virus

Frederick G. Hayden and Peter Palese

43. Bunyaviridae: Bunyaviruses, Phleboviruses, Nairoviruses, and Hantaviruses

Gregory J. Mertz

44. Arenaviruses

C. J. Peters

45. Enteroviruses

José R. Romero

46. Rhinovirus

Ronald B. Turner and Wai-Ming Lee

47. Hepatitis A Virus

Philip R. Spradling, Annette Martin, and Stephen M. Feinstone

48. Human Caliciviruses

Robert L. Atmar and Mary K. Estes

49. Hepatitis E Virus

David A. Anderson and Iswar L. Shrestha

50. Astrovirus

Ernesto Méndez and Carlos F. Arias

51. Coronaviruses

Kenneth McIntosh and J. S. M. Pieris

52. Arthropod-Borne Flaviviruses

Lyle R. Peterson and Alan D. T. Barrett

53. Hepatitis C Virus

Yaron Rotman and T. Jake Liang

54. Alphaviruses

David W. Smith, John S. Mackenzie, and Scott C. Weaver

55. Rubella Virus

David W. Kimberlin



Part C: Subviral Agents



56. Hepatitis D Virus

Antonina Smedile, Alessia Ciancio, and Mario Rizzetto

57. Transmissible Spongiform Encephalopathies

Adriano Aguzzi



Index

Editorial Reviews

5 Stars! from Doody

This book is a masterpiece. In 54 chapters, a world-renowned faculty has been assembled to comprehensively consider the pathogenic human viruses of medical importance. Constantly given short shrift in medical microbiology textbooks, viruses have long deserved a textbook of their own that integrates the basic science information with clinical, epidemiological, and therapeutic information, and this text does all that and more. The editors point out that clinical virology is the ""domain of molecular biologists, geneticists, pharmacologists, rnicrobiologists, immunologists, vaccinologists, practitioners of public health, epidemiologists, and clinicians, both pediatric and adult."" It is not an overstatement to say that individuals in any and all of these disciplines would benefit from having this book in their personal libraries. The book is divided into two sections: one describing viral syndromes/general agents, and one that considers individual agents on a pathogen-by-pathogen basis. The introduction provides a very useful and user-friendly overview of the sometimes confusing area of viral taxonomy, and the remarkable 16-page color insert provides some of the finest illustrations of classic viral syndromes ever collected in one text. A surprising feature of the text is its comprehensive and current reference list. For example, the chapter on Human Herpesvirus 8 goes far beyond the description of the association between this agent and Kaposi's sarcoma and delves into a very current overview of the viral genome, the effect of cytokines on the biology of the virus, and the current state of knowledge about the epidemiology of infection. This book fills a real void in the field, andis highly recommended as a comprehensive and important text for all medical school libraries, as well as the personal libraries of individuals who work with viruses in either the research or clinical care setting.

Mark R. Schleiss

Clinical Virology is a good, current, well-written resource for the wide range of individuals interested in the many aspects of virus biology and disease. Its consistent format makes locating specific information easy. The clinician may find the organization based on virus classification rather than symptoms a bit confusing, but will quickly discover the several different chapters devoted to agents that cause hepatitis, herpes, encephalitis, or hemorrhagic fever.

Journal of the American Medical Association

Reviewer: Rebecca T. Horvat, PhD, D (ABMM)(University of Kansas Medical Center)
Description: This is the third edition of a classic reference that reviews the current condition of clinical virology. The book is divided into two sections: the first reviews the clinical syndromes caused by viruses and the second contains chapters on specific viral pathogens. The last edition was published in 2002 and much has changed in clinical virology in those seven years.
Purpose: The purpose is to provide a comprehensive resource for "scientists and health care providers" on the changing nature of known viral pathogens and the discovery of new viral pathogens. It also provides reliable information on the rapid evolution of new methods used for testing, treatment, and prevention of viral diseases. This resource is clearly needed during a time of global travel and increasing recognition of new pathogens.
Audience: This book is written for professionals who work in the area of infectious disease. This would include scientists developing new antiviral agents and vaccines as well as practitioners making a diagnosis of infection in an increasingly vulnerable population. The authors of each chapter are respected authorities in virology and their contribution to this resource is clearly visible.
Features: Chapters in the first section review the clinical viral syndromes by organ system and illustrate the complexity of diagnosing viral diseases that can manifest with similar symptoms. This section also addresses the increased opportunity for viral infections in vulnerable populations, such as cancer and transplant patients, as well as neonatal patients. The large second section is classically organized by viral agents. These chapters provide details on the basic life cycle of the viruses, and the epidemiology and pathogenesis of viral infections in various hosts. Most of these chapters discuss diagnostic methods and treatment. Each chapter is packed with good references, diagrams of the disease process, and diagnostic markers used to determine the stage of viral disease.
Assessment: This is clearly one of the classic, need to have books for any scientist or healthcare provider who works in the area of viral infections. A large book, it weighs in at more than seven pounds, so would not be convenient to have available at the bedside. This is a reference that would be useful in an electronic format to provide this type of access.

Doody's Review Service