Urinary Tract Infections: Molecular Pathogenesis and Clinical Management / Edition 2

by Matthew A. Mulvey, David J. Klumpp, Ann E. Stapleton

Overview

A comprehensive overview of clinically important infections of the urinary tract Urinary tract infections (UTIs) continue to rank among the most common infectious diseases of humans, despite remarkable progress in the ability to detect and treat them. Recurrent UTIs are a continuing problem and represent a clear threat as antibiotic-resistant organisms and infection-prone populations grow.

Urinary Tract Infections: Molecular Pathogenesis and Clinical Management brings the scientific community up to date on the research related to these infections that has occurred in the nearly two decades since the first edition. The editors have assembled a team of leading experts to cover critical topics in these main areas:

• clinical aspects of urinary tract infections, including anatomy, diagnosis, and management, featuring chapters on the vaginal microbiome as well as asymptomatic bacteriuria, prostatitis, and urosepsis
• the origins and virulence mechanisms of the bacteria responsible for most UTIs, including uropathogenic Escherichia coli, Proteus mirabilis, and Klebsiella pneumoniae
• the host immune response to UTIs, the rise of antibiotic-resistant strains, and the future of therapeutics

This essential reference serves as both a resource and a stimulus for future research endeavors for anyone with an interest in understanding these important infections, from the classroom to the laboratory and the clinic.

If you are looking for online access to the latest clinical microbiology content, please visit www.wiley.com/learn/clinmicronow.

 

Product Details

ISBN-13:	9781555817398
Publisher:	Wiley
Publication date:	02/22/2017
Series:	ASM Books
Edition description:	2
Pages:	675
Product dimensions:	7.20(w) x 10.00(h) x 1.50(d)

Table of Contents

Contributors ix

Foreword xvii

Preface xix

I Clinical Aspects of Urinary Tract Infections

1 Anatomy and Physiology of the Urinary Tract: Relation to Host Defense and Microbial Infection Duane R. Hickling Tung-Tien Sun Xue-Ra Wu 3

2 Clinical Presentations and Epidemiology of Urinary Tract Infections Suzanne E. Geerlings 27

3 Diagnosis, Treatment, and Prevention of Urinary Tract Infection Paula Pietrucha-Dilanchian Thomas M. Hooton 41

4 Urinary Tract Infections in Infants and Children Theresa A. Schlager 69

5 The Vaginal Microbiota and Urinary Tract Infection Ann E. Stapleton 79

6 Asymptomatic Bacteriuria and Bacterial Interference Lindsay E. Nicolle 87

7 Bacterial Prostatitis: Bacterial Virulence, Clinical Outcomes, and New Directions John N. Krieger Praveen Thumbikat 121

8 Urosepsis: Overview of the Diagnostic and Treatment Challenges Florian M. E. Wagenlehner Adrian Pilatz Wolfgang Weidner Kurt G. Naber 135

II Origins and Virulence Mechanisms of Uropathogenic Bacteria

9 Reservoirs of Extraintestinal Pathogenic Escherichia coli Amee R. Manges James R. Johnson 161

10 Origin and Dissemination of Antimicrobial Resistance among Uropathogenic Escherichia coli Lisa K. Nolan Ganwu Li Catherine M. Logue 179

11 Population Phylogenomics of Extraintestinal Pathogenic Escherichia coli Jérôme Tourret Erick Denamur 207

12 Virulence and Fitness Determinants of Uropathogenic Escherichia coli Sargarunathan Subashchandrabose Harry L. T. Mobley 235

13 Uropathogenic Escherichia coli-Associated Exotoxins Rodney A. Welch 263

14 Structure, Function, and Assembly of Adhesive Organelles by Uropathogenic Bacteria Peter Chahales David G. Thanassi 277

15 Pathoadaptive Mutations in Uropathogenic Escherichia coli Evgeni Sokurenko 331

16 Invasion of Host Cells and Tissues by Uropathogenic Bacteria Adam J. Lewis Amanda C. Richards Matthew A. Mulvey 359

17 Proteus mirabilis and Urinary Tract Infections Jessica N. Schaffer Melanie M. Pearson 383

18 Epidemiology and Virulence of Klebsiella pneumoniae Steven Clegg Caitlin N. Murphy 435

19 Gram-Positive Uropathogens, Polymicrobial Urinary Tract Infection, and the Emerging Microbiota of the Urinary Tract Kimberly A. Kline Amanda L. Lewis 459

20 Integrated Pathophysiology of Pyelonephritis Ferdinand X. Choong Haris Antypas Agneta Richter-Dahlfors 503

III Host Responses to Urinary Tract Infections and Emerging Therapeutics

21 Susceptibility to Urinary Tract Infection: Benefits and Hazards of the Antibacterial Host Response Ines Ambite Karoly Nagy Gabriela Godaly Manoj Puthia Björn Wullt Catharine Svanborg 525

22 Innate Immune Responses to Bladder Infection Byron W. Hayes Soman N. Abraham 555

23 Host Responses to Urinary Tract Infections and Emerging Therapeutics: Sensation and Pain within the Urinary Tract Lori A. Birder David J. Klumpp 565

24 Drug and Vaccine Development for the Treatment and Prevention of Urinary Tract Infections Valerie P. O'Brien Thomas J. Hannan Hailyn V. Nielsen Scott J. Hultgren 589

Index 647